Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.

Tsutsumi, Naotaka; Masoumi, Zahra; James, Sophie C; Tucker, Julie A; Winkelmann, Hauke; Grey, William; Picton, Lora K; Moss, Lucie; Wilson, Steven C; Caveney, Nathanael A; Jude, Kevin M; Gati, Cornelius; Piehler, Jacob; Hitchcock, Ian S; Garcia, K Christopher.

Cell ; 186(19): 4189-4203.e22, 2023 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-37633268

2.

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.

Psaila, Bethan; Wang, Guanlin; Rodriguez-Meira, Alba; Li, Rong; Heuston, Elisabeth F; Murphy, Lauren; Yee, Daniel; Hitchcock, Ian S; Sousos, Nikolaos; O'Sullivan, Jennifer; Anderson, Stacie; Senis, Yotis A; Weinberg, Olga K; Calicchio, Monica L; Iskander, Deena; Royston, Daniel; Milojkovic, Dragana; Roberts, Irene; Bodine, David M; Thongjuea, Supat; Mead, Adam J.

Mol Cell ; 78(3): 477-492.e8, 2020 05 07.

Artigo em Inglês | MEDLINE | ID: mdl-32386542

3.

Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.

Cui, Lu; Moraga, Ignacio; Lerbs, Tristan; Van Neste, Camille; Wilmes, Stephan; Tsutsumi, Naotaka; Trotman-Grant, Aaron Claudius; Gakovic, Milica; Andrews, Sarah; Gotlib, Jason; Darmanis, Spyros; Enge, Martin; Quake, Stephen; Hitchcock, Ian S; Piehler, Jacob; Garcia, K Christopher; Wernig, Gerlinde.

Proc Natl Acad Sci U S A ; 118(2)2021 01 12.

Artigo em Inglês | MEDLINE | ID: mdl-33384332

4.

The thrombopoietin receptor: revisiting the master regulator of platelet production.

Hitchcock, Ian S; Hafer, Maximillian; Sangkhae, Veena; Tucker, Julie A.

Platelets ; 32(6): 770-778, 2021 Aug 18.

Artigo em Inglês | MEDLINE | ID: mdl-34097561

5.

Quantifying single-cell secretion in real time using resonant hyperspectral imaging.

Juan-Colás, José; Hitchcock, Ian S; Coles, Mark; Johnson, Steven; Krauss, Thomas F.

Proc Natl Acad Sci U S A ; 115(52): 13204-13209, 2018 12 26.

Artigo em Inglês | MEDLINE | ID: mdl-30530663

6.

Novel ET mutations: stuck in the MPL with you.

Hitchcock, Ian S.

Blood ; 135(12): 889-890, 2020 03 19.

Artigo em Inglês | MEDLINE | ID: mdl-32191801

7.

JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms.

Etheridge, S Leah; Roh, Michelle E; Cosgrove, Megan E; Sangkhae, Veena; Fox, Norma E; Chen, Junmei; López, José A; Kaushansky, Kenneth; Hitchcock, Ian S.

Proc Natl Acad Sci U S A ; 111(6): 2295-300, 2014 Feb 11.

Artigo em Inglês | MEDLINE | ID: mdl-24469804

8.

The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm.

Sangkhae, Veena; Etheridge, S Leah; Kaushansky, Kenneth; Hitchcock, Ian S.

Blood ; 124(26): 3956-63, 2014 Dec 18.

Artigo em Inglês | MEDLINE | ID: mdl-25339357

9.

A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis.

Etheridge, S Leah; Cosgrove, Megan E; Sangkhae, Veena; Corbo, Lana M; Roh, Michelle E; Seeliger, Markus A; Chan, Edward L; Hitchcock, Ian S.

Blood ; 123(7): 1059-68, 2014 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-24381227

10.

Thrombopoietin from beginning to end.

Hitchcock, Ian S; Kaushansky, Kenneth.

Br J Haematol ; 165(2): 259-68, 2014 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-24499199

11.

Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms.

Xu, Xiao; Gnatenko, Dmitri V; Ju, Jingfang; Hitchcock, Ian S; Martin, Dwight W; Zhu, Wei; Bahou, Wadie F.

Blood ; 120(17): 3575-85, 2012 Oct 25.

Artigo em Inglês | MEDLINE | ID: mdl-22869791

12.

Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.

Saur, Sebastian J; Sangkhae, Veena; Geddis, Amy E; Kaushansky, Kenneth; Hitchcock, Ian S.

Blood ; 115(6): 1254-63, 2010 Feb 11.

Artigo em Inglês | MEDLINE | ID: mdl-19880496

13.

Dissecting pathways to thrombocytopenia in a mouse model of visceral leishmaniasis.

Rani, Gulab Fatima; Preham, Olivier; Ashwin, Helen; Brown, Najmeeyah; Hitchcock, Ian S; Kaye, Paul M.

Blood Adv ; 5(6): 1627-1637, 2021 03 23.

Artigo em Inglês | MEDLINE | ID: mdl-33710338

14.

Hematological consequences of malaria in mice previously treated for visceral leishmaniasis.

Rani, Gulab Fatima; Ashwin, Helen; Brown, Najmeeyah; Hitchcock, Ian S; Kaye, Paul M.

Wellcome Open Res ; 6: 83, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34286101

15.

Bone marrow remodeling supports hematopoiesis in response to immune thrombocytopenia progression in mice.

Herd, Oliver J; Rani, Gulab Fatima; Hewitson, James P; Hogg, Karen; Stone, Andrew P; Cooper, Nichola; Kent, David G; Genever, Paul G; Hitchcock, Ian S.

Blood Adv ; 5(23): 4877-4889, 2021 12 14.

Artigo em Inglês | MEDLINE | ID: mdl-34428275

16.

YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation.

Hitchcock, Ian S; Chen, Maximus M; King, Jennifer R; Kaushansky, Kenneth.

Blood ; 112(6): 2222-31, 2008 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-18487512

17.

Quantitative Optical Diffraction Tomography Imaging of Mouse Platelets.

Stanly, Tess A; Suman, Rakesh; Rani, Gulab Fatima; O'Toole, Peter J; Kaye, Paul M; Hitchcock, Ian S.

Front Physiol ; 11: 568087, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-33041864

18.

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.

Wilmes, Stephan; Hafer, Maximillian; Vuorio, Joni; Tucker, Julie A; Winkelmann, Hauke; Löchte, Sara; Stanly, Tess A; Pulgar Prieto, Katiuska D; Poojari, Chetan; Sharma, Vivek; Richter, Christian P; Kurre, Rainer; Hubbard, Stevan R; Garcia, K Christopher; Moraga, Ignacio; Vattulainen, Ilpo; Hitchcock, Ian S; Piehler, Jacob.

Science ; 367(6478): 643-652, 2020 02 07.

Artigo em Inglês | MEDLINE | ID: mdl-32029621

19.

Thrombopoietin promotes beta1-integrin-mediated adhesion in hematopoietic cells via the small GTPase Rapl.

Hitchcock, Ian S; Kaushansky, Kenneth.

Exp Hematol ; 35(5): 793-801, 2007 May.

Artigo em Inglês | MEDLINE | ID: mdl-17577928

20.

CD4⁺ T Cells Alter the Stromal Microenvironment and Repress Medullary Erythropoiesis in Murine Visceral Leishmaniasis.

Preham, Olivier; Pinho, Flaviane A; Pinto, Ana Isabel; Rani, Gulab Fatima; Brown, Najmeeyah; Hitchcock, Ian S; Goto, Hiro; Kaye, Paul M.

Front Immunol ; 9: 2958, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30619317

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